The study of human emotions and personality provides valuable insights into the p arameters of mental health and well-being. Affective neuroscience proposes thatseveral levels of emotions – ranging from primary ones such as LUST or FEAR up to higher emot ions such as spirituality – interact on a neural level. The present study aimed to furth er explore this theory. Furthermore, we hypothesized that personality – formedby bottom-up primary emotions and cortical top-down regulation – might act as a linkbetwe en primary emotions and religious/spiritual well-being. A total sample of 167 (78% femal e) student participants completed the Affective Neuroscience Personality Scale(primary e motions), the Big Five Personality Inventory and the Multidimensional Inventoryof Religious/Spiritual Well-Being (higher emotions). Correlation analyses confirmed thelink between primary and higher emotions as well as their relation to personality. Furtherregr ession analyses indicated that personality dimensions mediate the relationshipbetwee n primary and higher emotions. A substantial interaction between primaryemotions, personality dimensions, and religious/spiritual well-being could be confirme d.From a developmental perspective, cortical top-down regulation might influence
religious/spiritual well-being by forming relevant personality dimensions. Hence, CARE as well as Agreeableness seem of special importance. Future studies might focus onimplications for clinical groups.