In total 420 persons of both sexes were examined: Religiosity and spirituality were investigated in clinically well characterized detoxified addicts (N=120), depressive in-patients (N=100), and persons with no psychiatric diagnosis/treatment in their biography (N=200) using a Multidimensional Inventory for Religious-Spiritual Well-Being (MIRSWB 48) in combination with the Centrality Scale (C-Scale) and the Structure of Religiosity Test (RST). Personality dimensions were investigated using the Six Factors of Personality Test (6F Test). In psychiatric patients the psychopathological dimensions were assessed using the Brief Symptom Inventory (BSI), the Beck Depression Inventory (BDI), the Brief Psychiatric Rating Scale (BPRS), and the Montgomery Asberg Depression Rating Scale (MADR-S). Data were evaluated with X2 Test and Correlation/Regression analysis. General Linear Model multivariate (parametric) and Kruskal-Wallis H Test (non parametric) were conducted for multiple group comparisons. Women showed to be more religious-spiritual than men and there was a positive association between religiosity/spirituality and age. Depressive patients turned out to be the most religious-spiritual, addicts the least. The personality dimensions Piety, Extraversion and Openness showed to be positive predictors of religiosity/spirituality, Neuroticism and Aggressiveness were found to be respective negative predictors. Psychopathological symptoms were the strongest negative predictors of Hope and Forgiveness as religious-spiritual dimensions. The more central the individual religious-spiritual construct system is, the more powerful are its effects. There is a relevant mutual association between religiosity/spirituality, personality, and psychopathological symptoms, in dependence of the centrality of the individual religious-spiritual construct system. Thus integrating of religious-spiritual issues might open up new strategies in diagnosis, prevention, and therapy of psychiatric diseases.